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KMID : 0357919860200040442
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Korean Journal of Pathology
1986 Volume.20 No. 4 p.442 ~ p.452
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Ultrastructural Observations on Human Primary Hepatocellular Carcinomas -Analysis of 35 Lobectomy Specimens-
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Abstract
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The etiologic impacts in primary hepatocellular carcinoma among Koreans seem
different from those in other countries with its high incidence and close association of
hepatitis B virus infection and liver cirrhosis. A series of 35 lobectomy specimens of
hepatocellular carcinoma (HCC) was examined by means of electron microscopy to
elucidate the general ultrastructural characteristics and to understand the morphogenesis
of various histological growth patterns and cytologic features of HCC.
1) General cytological details of HCC were similar to those of non-neoplastic
hepatocytes, but characterized by scantiness of subcellular organelles. Degree of cellular
differentiation was not correlated with ultrastructural features of HCC.
2) Acinar pattern of HCC seemed to develop by either dilatation of central bile
canaliculus or central cystic degeneration of microtrabecular growth, and clear cell group
of HCC was expressed in abundance of glycogen particles and lipid droplets.
3) Intranuclear inclusions of HCC proved to be cytoplasmic herniations of tumor cells,
and intracytoplasmic tubular arrays appeared to originate from the endoplasmic
reticulum.
4) Hyaline globules seen in HCC corresponded to clumps of microfilamentous structures
similar or identical to Mallory's hyalin.
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